Hormones are chemicals the body naturally makes to control the growth and activity of normal cells. Hormones can also speed the growth of some types of cancer. For example, the hormones estrogen and progesterone can stimulate the growth of some breast tumors.
Cancer of the endometrium is characterized by the presence of cancer cells in the lining of the uterus or wombor endometrium. Treatment options depend on a number of factors, including the stage of disease extent of disease at diagnosis. Many of these women receive hormone therapyusually with a progestin type of female hormone called megestrol acetateto help control the symptoms of disease and prolong survival time.
Anorexia-cachexia syndrome ACS is a common clinical problem that substantially impacts upon the quality of life and survival of affected patients. More than two-thirds of patients dying from advanced cancer suffer from anorexia-cachexia syndrome 3. ACS is also described in other pathologies such as in acquired immune deficiency syndrome AIDSanorexia nervosa, degenerative illnesses of the central nervous system and terminally ill patients 4.
However, long-term chemotherapy is often difficult due to adverse effects. The two groups were matched at a ratio according to age, metastatic sites, and salvage treatment lines. Progression-free survival PFS was calculated using the Kaplan—Meier method, and the two groups were compared using the log-rank test. Eight patients discontinued chemotherapy due to adverse effects, and one patient withdrew from MPA treatment because of weight gain.
This page contains brief information about megestrol acetate and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. FDA label information for this drug is available at DailyMed. Megestrol acetate in tablet form is approved for palliative treatment of advanced disease in:.
Hormonal therapy is a treatment that adds, blocks or removes hormones to slow or stop the growth of cancer cells that need hormones to grow. Hormonal therapy is also called hormone withdrawal therapy, hormone manipulation or endocrine therapy. Hormonal therapy may be used alone as the main treatment or with other treatments.
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Hormone therapy using megestrol may fight cancer by reducing the production of these hormones. Evaluate the clinical effects of high-dose oral megestrol in improving regression rate and prolonging survival in patients with breast or endometrial carcinoma or mesothelioma. Evaluate the immune, endocrine, and clinical effects of this regimen, with particular attention to effects on cachexia.
Breast cancer is the most common cancer in women worldwideand the second-most common cancer overall, with more than 1, people diagnosed in Although advances in screening, surgical intervention, radiotherapy and systemic therapies have improved survival, aroundwomen died from breast cancer in worldwide. There is an urgent need for better treatment strategies.